Myeloperoxidase: a target for new drug development?

Inhibition of Myeloperoxidase: a New Therapeutic Target

Cdc7 kinase - a new target for drug development.

The cell division cycle 7 (Cdc7) is a serine threonine kinase that is of critical importance in the regulation of normal cell cycle progression. Cdc7 kinase is highly conserved during evolution and much has been learned about its biological roles in humans through the study of lower eukaryotes, particularly yeasts. Two important regulator proteins, Dbf4 and Drf1, bind to and modulate the kinase...

Kinetoplast DNA: A Promising Drug Target for Treatment of Leishmaniasis

Leishmaniasis is a vector-borne zoonotic disease caused by various species of the genus Leishmania, (trypanosomatidae family) that is transmitted by phlebotomine sandflies. The disease can present in a range of clinical forms, including dermal lesions, metastasis mucocutaneous forms, and fatal visceral forms. In this non-systematic review, we aimed at introducing the role of kinetoplast DNA (kD...

P14: Mitochondria as a Target for Drug Therapy in Epilepsy

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Mycotoxin- A Target for Anticancer Drug Development

The aim of this present article is to underscore the recent evidence linking anticancer activity and free radical scavenging activity of mycotoxins and its significance in the development of newer anticancer drugs. Although acute exposure to a massive amount of mycotoxin is rare but long-term exposure/consumption of food with low levels of lipophilic mycotoxin remains problematic. The aneuploid...